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Crazy asked in Science & MathematicsMedicine · 2 months ago

How does Naproxen and other NSAIDs affect norepinephrine and other monoamines?

https://pubmed.ncbi.nlm.nih.gov/26894935/

It's not clear to me. So Naproxen causes increase or decrease? 

1 Answer

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  • 2 months ago

    Norepinephrine is released into the synaptic cleft (space between two neurons). It is then pulled back into the originating neuron.

    This is cyclic as it repeats over and over. The medical effect occurs when it is in the cleft not in the neuron.

    NSAIDs block reuptake in the neuron keeping more in the synapse. This causes an increase in effect and possible overdose.

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