Expression of Telomerase?
Immortality of Stem cells is supported by the expression of telomerase that can extend the telomere sequence. However, one daughter cell created by division of stem cells will not be immortal due to lack of telomerase expression.
a) What difference will you expect in regulation of the telomere coding gene between the two daughter cells produced by cell division of stem cells? How might the cells be different in terms of chromatin structure at that loci?
b) What kind of protein/molecule can make the difference in the two daughter cells? And how can they make that difference?
I think part (a) could be explained through asymmetrical cell division. But need some guidance on part b.
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