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Anonymous asked in Science & MathematicsChemistry · 2 months ago

Chemistry ?

An Arg residue is mutated to Ala in a receptor. Ligand binding to this receptor decreases 100-fold. What does this tell you about the interaction between the ligand and receptor? 



1 Answer

  • 2 months ago

    Because the side chain of Arg is positively charged, the result suggests that the interaction with the receptor involves a critical electrostatic attraction between the positive Arg residue with some perhaps negatively charged portion of the ligand.

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