asked in Science & MathematicsChemistry · 3 weeks ago

Under acidic condition, why nucleophile more likely to attack more substituted Carbon next to oxygen?

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  • 3 weeks ago
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    In acidic condition, oxygen in C=O group is protonated and becomes C=OH⁺. OH⁺ is a strongly electron-withdrawing. By inductive effect, the C atom in C=OH⁺ carries a significant partial positive charge, and thus the C atom accepts the lone pair of electrons much readily.

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