Under acidic condition, why nucleophile more likely to attack more substituted Carbon next to oxygen?
- 冷眼旁觀Lv 63 weeks agoFavorite Answer
In acidic condition, oxygen in C=O group is protonated and becomes C=OH⁺. OH⁺ is a strongly electron-withdrawing. By inductive effect, the C atom in C=OH⁺ carries a significant partial positive charge, and thus the C atom accepts the lone pair of electrons much readily.