For US launches, the last STS mission, but far from the last American in space.
Astronauts are hitching rides to ISS on Soyuz.
WRONG,,,The US space program is very far from dead, more research effort in further out from the moon with probes the current priority in preparation for manned missions to Mars. Some plans on the table of back to the moon, but still on the back burner. A new space telescope and new Hall plasma drive coming up very soon.
As for launching man into space,,sure,,any time, just say the word and put up the added billions to do it.
Even private enterprise is doing it.