It depends on what you consider "best" and what you want to do on your vacation. If you want to visit theme parks and zoos, then the Orlando and Tampa areas will be best for you. If you want clear and often (but not always) quiet beaches, then the Gulf Coast might be best for you. If you want big waves and more touristy cities, then the Atlantic coast will be best. There are a whole lot of other options in FL - it's a big state with a lot to do. Research it online, ask friends, go to travel sites and read blogs and forums, etc.