Not without great risk of crashing. It's unlikely that your flight simulator would be an exact replica of the particular plane you're trying to fly, and certainly no book is going to teach you about that specific aircraft. No flight simulator can teach you the real world, seat-of-the-pants feel to flying to understand exactly how the aircraft handles. You'd have to know all about weather to know you're not headed into a towering cumulus (which may develop into a thunderstorm) or severe icing conditions. You'd have to know all the regulations to follow, especially if you're flying in controlled airspace. You'd have to know what frequencies to tune in to talk to someone and know if there's any air traffic around to see and avoid. You'd have to know what all the various aircraft speeds are: stall speeds, maneuvering speed, minimum control airspeed (more pertinent with twin engine planes in case of engine failure), landing speeds, etc. You'd need to know how to handle any emergencies that come up. And you'd have to know how to do a proper approach, flare, and landing without smashing the plane up, all of which come with that seat-of-the-pants feel and experience through actual real world training with a flight instructor. There are countless things that can go wrong if you don't go through proper flight instruction with both air work and ground classes.
airplane pilot since 1995