I presume you mean in the physical sciences, since that is where your question is posted.
The days of huge advances are long gone, over a century ago.
Knowledge is like any other resource: the more we harvest it, the more difficult and expensive it gets to find and harvest whatever else there is. Obviously we acquired the "lowest hanging fruit" first, such as fire, the lever, the ramp and so forth. These principles were easily available and easy to convert to technology.
Roll forward many millenia and we discovered the electromagnetic theory, lenses, the prism. These required little more than some wire, magnets, and glass. They were used to make lenses, telescopes, microscopes, and the telegraph. Once again, relatively cheap to get and easy to convert to technology.
Then there was radio toobs. The result was wireless communications, x-ray machines, and radar. Big step up in difficulty level and cost, notice.
Radiation was next. The necessary technology was a huge "atomic pile" built at great cost under a stadium, and millions of dollars invested to weaponize it.
Roll forward to today: we see that the quest to discover "new science" requires billions of dollars and multinational cooperation as witnessed by the LHC, JWST, LIGO, ISS and other humungus projects, which due to diminishing returns yield little if any new science.
There may be science in nature that we don't know about, just as there is oil in poor quality and deep within the Earth. The fact is that in such cases, the cost and effort to even try to exploit such knowledge or resources becomes greater than what the world can now afford to spend, and the complexity and sheer size of the construction required defeats even international effort.
Poignantly, seeing that there are now 8 billion people in the world, we need all the basic commodities such as water, food, and jobs just to provide for them all. We are predictably enough, reaching the stage where there is not enough global productivity left to support massive spending in the sciences, arts, health care, education or much else that is optional above and beyond desperate survival.
In all likelihood, in centuries to come when it will be possible to look back objectively upon the current times, we will see that technology followed something like a bell curve, peaking around now. From here, as resources dwindle, and the wars and famines kick in, the only direction for technology is back towards very early industrial age steam punk.
The Jetsons was a happy dream, a fantasy of optimism from a bygone era. Now we can only look forward to living like the Flintstones. Or if we are very lucky, like the ancient Egyptians.