I think the Democratic party will attempt to sabotage him every point along the way, just like they did in 2016. Yet despite being sabotaged by the DNC, he came within an inch of winning the nomination against a much better known woman who has been famous for 20+ years. However, that 2016 election has now given him huge name recognition, celebrity status. So it will be considerably harder to knock him out this time.
One thing different that's going to happen in the next election is that there is going to be a hell of a lot of different candidates for president on the Democratic side, both among progressives and centrists. The progressives are people like Bernie, Elizabeth Warren, and Tulsi Gabbard. The rest are centrists, such as Kamala Harris, Cory Booker, Kirsten Gillibrand, etc. I know that those last three are called "progressives" by the media, but that's disingenuous, they have been centrists for most of their lives, and have only recently started saying progressive things. Also Joe Biden is a through-and-through centrists, he isn't even trying to pretend to be a progressive, like these other ones.
I figure in the end it's going to come down between Bernie and Biden. The other candidates may continue on into the Democratic convention and it may go to a 2nd round vote, for the first time in 50 years or so. If it goes to a 2nd round, then I think Biden will win. If it's over in the 1st round, then it will be Bernie who takes it. It's just a matter of whether the other centrists and other progressives throw their support towards Biden or Bernie. I think Bernie and Warren may have a secret deal with each other to drop out and throw their support to one or the other, so it doesn't split the progressive vote too much. The centrists may not have any agreements in place with each other, and so they will split up the centrist vote heavily, letting the progressive win.