I think so! I went to a large high school (about 3,000 people) and I'm going to an even larger college (around 28,000 people). I think the big difference for me is that no one cares. You can dress however you want--no one cares. You can walk around with earbuds in just going from one class to another, you can sit and take a nap in public, you can have friends or be a complete loner, and no one cares. Everyone is so wrapped up in their own world that no one thinks about you. It's awesome. You're also more responsible for your own work and studying in college, which I prefer. I like to be able to take notes however I want, study how I want, and not have busywork assignments. If you aren't organized and on top of things, you can start falling through the cracks quickly though.
My biggest advice: learn how you study and DO THAT. Study better, not harder. Being efficient is what separates people who stay up until 3am studying for a test from those who are only up until 9pm. Make friends in every class if you can, because if you miss a day you're going to want the notes, and it helps to have someone to study with. Get involved in SOMETHING because networking is everything. If your specific major or program has some sort of club or organization, get in it. GET AN INTERNSHIP. Employers remember good interns, I cannot stress this enough. That is the key to landing a job. Your university almost certainly has someone who can help you find an internship, whether it's within your department or a career center of some sort. Use them. Talk to your professors. Go to office hours. Get help if you need it and do it as soon as you realize you're struggling. Ask questions. Get a planner and stay organized. Write down all your deadlines as soon as you get them (first week = syllabus week = write all your test dates and due dates in your planner and check it frequently).