I take it for depression and for pain. About three hours after my first dose, it made me vomit. On the way to the bathroom, I realized the pain in my feet and ankles was almost gone. Then my breathing took slightly more effort and was slightly more rapid. Then every joint in which I have arthritis started to have a tingling vibration feeling. Then it felt like my vision, hearing, and thoughts were being processed at different rates by my brain, like when the audio and visual tracks don't match up on tv. That all lasted about two hours then I went to sleep and had three of the strangest dreams I ever had. The only side effect I have now is random parts of my body will twitch as I am about to fall asleep. I didn't have any problems when my dose was increased. It helped my physical pain a lot, but only helped my depression somewhat.