Well it depends on if you want an actual "stone" or a nice machine that does it. Actual stone, then not possible. But if you want to make gold (which is what I'm assuming, having never seen the show), you can produce gold in collisions in particle accelerators. This is very impractical, as the amount of gold produced is very low, and it would cost more money (much much more) to produce it. You would be better off trying to synthesizing antimatter, somehow stabilizing it, and finally selling that for practically all the gold on the planet.