Neurons, fill in the blank question?
__________ can excite almost every Neuron in the brain and the Nervous System, whereas _________ has an inhibitory effect on the brain.
I'm pretty sure the second option is GABA but I don't know what the first is.
These are the options: GABA
neurotrannsmitters terminal axon
lock and key
bind synaptic cleft
- John TLv 53 years agoBest Answer
1. Glutamate (it depends on the receptor function. Most are excitatory)
2. GABA (you're correct. Again, it depends on the receptors but most are inhibitory)
Take home message
The action of a chemical signal (a ligand) is determined by the function of the receptors to which it binds.
So even though your lecture or book say, X is an excitatory neurotransmitter and Y is an inhibitory transmitter, this is not completely accurate.
What is Acetylcholine (Ach)? Well, it can be either type. If it binds nAChRs on postganglionic fibers or skeletal myocytes, Ach excites these cells. However, if it binds mAChRs on the heart, heart rate decreases, so you might call this effect inhibitory. mAChRs even have subclasses. mAChRs in the digestive glands, lets use the stomach would bind Ach and stimulate acid secretion in the stomach, so you would call this case excitatory.
I hope this makes sense. The classification of NTs as excitatory or inhibitory is based on the function of the receptors to which they bind.
- 3 years ago