The reaction "cascade" in glycolysis can't contribute without unloading --- from NADH?
Hydrogen, oxygen, or nitrogen.
- Ted KLv 73 years agoFavorite Answer
A key reaction in glycolysis is the conversion of glyceraldehyde 3-phosphate (G3P) to 1,3, diphosphoglycerate, catalyzed by the enzyme, G3P dehydrogenase, which requires NAD+ (i.e. the oxidized pyridine nucleotide) as a cofactor. Under aerobic conditions, NADH --> NAD+ by giving up its H+ to the electron transport chain. Under anaerobic conditions the NAD+ is regenerated by reducing pyruvate to lactate.