求paper翻譯~英文~

Another mouse model of sleep apnea utilizes New Zealand Obese mice; these mice have many characteristics of the metabolic syndrome such as diabetes, hyperlipidemia, and hypertension . However, spontaneous OSA is not a common condition in animals and as such is not easy to observe and evaluate the metabolic and cardiovascular consequences of this disorder under experimental settings.This has led to alternate strategies to study sleep apnea in laboratory animals, as discussed below.

OSA can be simulated through surgical procedures inducing airway obstruction.

This procedure has mainly been used in larger animals such as dogs, piglets , and baboons and small rodents. Studies have incorporated sophisticated apparatus that is able to detect sleep–wake states. Therefore, the initiation of airway obstruction is closely coordinated with sleep onset. In a recent study, researchers implanted an inflatable tracheal balloon that induces obstructive apnea, along with a mediastinum balloon-tipped catheter for the measurement of intrathoracic pressure. This method combined with procedures of sleep and respiratory cycle detection allows induction of sleep apnea that starts at a fixed point in the respiratory cycle – so more closely imitating human OSA, which typically occurs during early inspiration . However, this procedure is invasive. To ameliorate the degree of invasiveness, a specific chamber was designed with body and head chambers with a neck collar that applies recurrent airway obstruction. Unfortunately, this method restrains the animal movement and imposes a lot of stress .

The most widely used animal model of sleep-disordered breathing is the IH model, where small animals such as mice and rats are placed in specific chambers where ambient gases are tightly controlled.In these chambers, a control system regulates the flow of room air and nitrogen.

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  • Anonymous
    6 years ago
    Favorite Answer

    大大你好,讓我為你解答:

    睡眠呼吸暫停的另一種小鼠模型中採用新西蘭肥胖小鼠;這些小鼠具有代謝綜合徵的許多特徵,例如糖尿病,高脂血症和高血壓。然而,自發OSA不能在動物中一種常見的疾病,因此,不容易觀察和評價的代謝和這種疾病根據實驗settings.This的心血管後果,導致備用策略來研究睡眠呼吸暫停中的實驗室動物,如下面所討論。

    OSA可以通過外科手術引起的氣道阻塞進行模擬。

    此過程主要使用在較大的動物如狗,豬和狒狒和小囓齒動物。研究已經併入了能夠檢測睡眠 - 覺醒狀態的複雜的裝置。因此,氣道阻塞的啟動密切配合入睡。在最近的研究中,研究人員植入一個充氣的氣球氣管誘導阻塞性呼吸暫停,連同縱隔球囊導管尖端為胸內壓測量。此方法結合睡眠與呼吸週期的檢測程序使得感應的睡眠呼吸暫停,在一個固定的點,在呼吸週期的開始 - 因此更密切模仿人類的OSA,其通常在早期靈感發生。然而,這個過程是侵入性的。為了改善侵入的程度,特定的室內設計有身體和頭部室與適用復發呼吸道阻塞頸托。不幸的是,這種方法限制了動物的運動和施加了很大的壓力。

    的睡眠呼吸紊亂的最廣泛使用的動物模型是IH模型,其中的小動物如小鼠和大鼠被放置在特定的腔室,其中周圍的氣體被緊緊controlled.In這些腔室中,控制系統調節室內空氣的流量和氮氣。

    希望有幫助到你!

    Source(s): 自己
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    6 years ago

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