求~醫學英文翻譯

Nevertheless, in this study inevitably remain some limitations,

which should be under particular consideration.

First, SHYGC concentration in rabbit sera was just

assumed to attain the steady state (Css) at the time of

collecting drug-containing sera, which was based on

the principle of pharmacokinetics, in which serum drug

concentration is gradually elevated to Css by multiple

doses. Typically, if dosing interval is drug half-life (t1/2),

the serum drug concentration will achieve Css in 5 to

7 t1/2 s. However, it is extremely difficult to obtain the

exact t1/2 of SHYGC, that is composed of 6 Chinese

herbs and a number of bioactive components with various

t1/2 s, although the pharmacokinetics investigation of

SHYGC would be supplementary to this study. On the

other hand, Css is not essential for seropharmacological

study, although the higher serum drug concentration is

absolutely beneficial to the research. Second, in seropharmacological

study including our research, healthy animals

are commonly recruited to prepare drug-containing sera

, but the animals with specific disease should be

superior to healthy animals for this point, because the

internal process of drug in animals with disease of

interest is more close to that in human patients, and

animals of disease model could differ significantly from

healthy animals in the biotransformation and metabolism

of drug, which may be a critical factor to influence the

ingredients of drug-containing serum. However, there

is a long way to go to establish various animal models

of specific disease for seropharmacological research.

Third, notwithstanding seropharmacology is a combination

of in vivo and in vitro tests, it can not entirely

represent the study in vivo, because the true effectiveness

of drug in the body may be affected by other factors, such

as the level of drug receptor in the body, the affinity of

drug to receptor, the physical response to drug, etc.

4 Answers

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  • Chris
    Lv 7
    6 years ago
    Favorite Answer

    然而 這項研究中無可避免地留有一些局限 應予以特別的考量

    第一 SHYGC(三黃乙肝膠囊 治肝炎的中藥)在兔子血清中的濃度只是臆測在採取含葯血清時有達到穩定狀態濃度 這是基於藥物動力學的原則 血清藥物濃度以多次劑量給予可逐漸提升到穩定狀態濃度

    典型地 若施藥間隔是依照葯的半衰時間(t1/2半衰期)則經由5-7次的半衰期施藥 血清藥物濃度將達到穩定狀態濃度 但是要取得由6種屮草葯以及許多各具不同半衰期的生化成分所合成的SHYGC的確實半衰期是極度困難的, 雖然SHYGC的藥物動力學調察只是本研究的附加補充 另方面說來 穩定狀態濃度對於血清藥理學研究並非實質必須的 雖然較高的血清藥物濃度對研究是絕對有助益的

    第二 血清藥理學研究包括我們的研究通常都是以健康動物來準備含葯血清 但是在這點上 有特定疾病的動物應該優於健康動物 因為藥物在有相關疾病的動物的內部進行過程比較接近人類病患內的過程 而且有疾病動物與健康動物在藥物的生化轉換以及新陳代謝上別具不同 這可能是一個影響含葯血清的成分的重要因素 但是要為血清藥理研究建立各種特定疾病的動物範本還有一條長路要走

    第三 儘管血清藥理學是一項活體及試管測試的結合 並不能完全代表活體內的研究 因為藥物在身體內的真正效力會受其他因素影響 例如身體內藥物受體的高低 藥物對受體的親近性 對藥物產生的生理反應,等等

    註 Css - concentration at steady state 是指血內平均藥物濃度不會中毒又剛好是最佳療效的濃度 稱為穩定狀態濃度

    以上供參

    2014-05-06 04:35:57 補充:

    在這麽多醫學翻譯發問中 選你的問題回答是因為你上次發問有自選解答

    其實可以翻譯的高手在所多 但有太多的發問者將問題置之不理流於票選 醫學翻譯並不是很簡單的事 若是辛苦打字 被人棄之如敝履 甚或輸給語無倫次的google翻譯 再有風度的人亦不能不感覺受辱 這就是爲何都沒有人回答 或就算回答也常放意見欄的原因 以免嘔氣

    個人認為 發問者會來發問當然就是看不懂 也就很有可能無法確定選出最佳解答 所以我不介意開放投票 但發問者至少應該也投下一票以示負責 我不敢自詡百分百正確 但敢負責的說力求信達雅 希望發問人也能負起最簡單的責任 謹祈

  • Anonymous
    6 years ago

    參考下面的網址看看

    http://phi008780508.pixnet.net/blog

  • 意見者:bjchiou ( 大師 4 級 )

    擅長領域: 英文 | 作業系統

    發表時間:2014-04-16 01:42:50

    醫學專業神人在此,雞蛋裡骨頭;然後剪開你的傷口灑鹽是他的專業強項!

  • Anonymous
    6 years ago

    參考下面的網址看看

    http://phi008780430.pixnet.net/blog

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