For each of the following drugs, state how they would affect neural communication (i.e. resting membrane potential, graded potential, action potential, or synapse). HINT: Think about where each of these channels are located. If they are blocked what does that lead to?
a. Tetrodotoxin-inhibits voltage gated sodium channel blocker
b. Oligomycin - inhibits ATP synthesis
c. α-Bungarotoxin - Ach-R antagonis
d. Vanadate - inhibits Na+/K+ ATPase pump
e. Dantrolene - RyR inhibitor
f. Ziconotide - inhibits voltage gated calcium channels
g. Excess Nicotine
h. Genistein - blocks potassium leak channels!
i do not get this...please help ):
- 6 years agoFavorite Answer
In order to answer this question, you need an understanding of what each of these channels/proteins do!
Tetrodotoxin blocks v-gated na channels. V-gated Na channels are responsible for the rising phase in action potential. When they open, sodium rushes into the neuron along its concentration gradient. Blocking these channels inhibits action potential.
I will come back later to help you with the others, but figuring these answers out on your own would help you a TON for any future exam.