I wouldn't say it's over. However he's been out of the game for a while. And he's taking way to long to get his album released, and frankly I think people are just losing patience and interest.
Also, 50 is a legend, and wants nothing to do with fake rappers like Kendrick and Drake. I've never heard of those other nobodies. Try listening to some real artists. If 50 appeared on their albums, he would look bad for it.
If 50's new album gets enough attention, he'll probably do a collaboration with G-unit, which would blow the rap game away. Lloyd Banks, Tony Yayo and Young Buck have been working in studios with each other lately, so I have a feeling something G-UNIT is about a pop off.
You obviously know nothing about rap. You're probably some 10 year old kid who read some youtube comments and believed whatever you saw. You wouldn't have the first idea as to what his relationship with his kids are like. Everyone's dissing him? No. 50 dissed Kanye West's crossdressing on his new songs, which has been a long time coming. Rap is NOT about dresses and sell-out artists.
50's new album will be a success. But if he really wants to blow everyone's mind away, he'll need to get G-unit back together. One last album with the unit, and then I'd be comfortable with him retiring from the rap game. It's basically dead anyway..