State the reason why plasmids have an origin of replication?
Just want to know why plasmids have an origin of replication?
What does it mean that plasmids have a MCS (multiple cloning sites) ?
- BonnieLv 47 years agoFavorite Answer
An origin of replication is a sequence of DNA at which replication is initiated on a chromosome, plasmid or virus. For small DNAs, including bacterial plasmids and small viruses, a single origin is sufficient. Larger DNAs have many origins, and DNA replication is initiated at all of them; otherwise, if all replication had to proceed from a single origin, it would take too long to replicate the entire DNA mass.
An essential feature of bacterial plasmids is their ability to replicate as autonomous genetic elements in a controlled way within the host. Plasmids are extrachromosomal DNA elements with characteristic copy numbers within the host.