m89065 asked in 社會與文化語言 · 7 years ago


Purpose: Malnutrition and chronic inflammation in dialysis patients negatively impacts prognosis. However, intervening to correct this problem (through nutritional supplementation) is often hampered by poor compliance due to both medical and socioeconomic barriers. We have therefore performed a pilot study to investigate the technical feasibility of “directly observed treatment” of nutritional supplementation (protein and omega-3 fatty acids), administered during regular dialysis sessions. Secondary end points included observation of nutritional and inflammatory status of hypoalbuminemic patients undergoing hemodialysis.

Methods: Main inclusion criteria were serum albumin # 3.9 g/dL (3 months prior to the study).Sixty-three eligible patients agreed to participate. Two intervention groups received 30 mL of a liquid protein supplement plus either 2.4 g omega-3 (1800 mg eicosapentaenoic acid + 600 mg docosahexaenoic acid) or a placebo, three times per week after their routine dialysis session for 6 months. Serum albumin, plasma lipids, and other indicators of nutritional and inflammatory status were measured.

Results: Directly observed nutritional supplementation resulted in a significant improvement in the low density lipoprotein cholesterol/high density lipoprotein cholesterol ratio in the omega-3 group as compared to the placebo group (P = 0.043). For the omega-3 group, serum albumin was also marginally higher after 6 months as compared to baseline (P = 0.07). The observed increase in C-reactive protein in the placebo group over 6 months was not apparent in the omega-3 group, although there was no significant difference between groups. Nuclear factor kappa B, malnutrition-inflammation score, normalized protein nitrogen appearance, body mass index, and hemoglobin were unaffected by the intervention.


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2 Answers

  • 7 years ago
    Favorite Answer



    結果:直接觀察到的營養補充,導致在一個顯著的改善,低密度脂蛋白膽固醇/高密度脂蛋白膽固醇的比例ω-3組較安慰劑組(P=0.043)。對於ω-3組中,血清白蛋白也略高基線(P=0.07)相比,6個月後。超過6個月,而安慰劑組的C-反應蛋白明顯上升並不明顯的ω-3組,組之間雖然沒有顯著的差異。核因子kappa B,營養不良炎症評分,外觀正常的蛋白質氮,身體質量指數和血紅蛋白不受干預。

    Source(s): Googel
  • Anonymous
    7 years ago

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