What's the adult dosing for pernicious anemia?

case study: the pt has a long history of vitamin B 12 deficiency & throughout the years he has been getting 1000mcg IM treatment. he began w/ the standard 1000mcg IM qd x7 then 1000mcg qw x4w & 1000mcg qm x3m.

intermittently, the pt does not always order refills so he might not inject his monthly dose every month. after 6 months of not injecting, he is seen by the doctor again, the diagnosis... pernicious anemia.

what would the patient's dose be? would 1000mcg once monthly be prescribed, or would 1000mcg qd x7d followed by a once weekly dose for a month followed by a monthly dose be more appropriate? keep in mind he has always had problems w/ his vitamin B12 levels.

(if u say he needs to be prescribed other vitamin B or folic acid or even one or two antimicrobial drugs, i'll agree w/ u)

Thanx in advance!

2 Answers

  • Anonymous
    8 years ago
    Favorite Answer

    According to current medical diagnosis & treatment 2013, the standard treatment is 100 mcg IM on that regimen that you mentioned.

    I would guess that if someone went off their treatment for 6 months and was diagnosed with pernicious anemia, they should do the standard regimen with 100 mcg again.

    The book also mentions that it is important to do a differential diagnosis to determine whether it would be folic acid deficiency which is the other common cause of megaloblastic anemia. However, in the case of a folic acid deficiency, a lab test would show normal B12 levels.

    If B12 and folic are normal, perhaps it's megalodysplasia caused by megalodysplastic syndrome or acute erythrocytic leukemia (differential characteristics that separate megalodysplasia and B12 deficiency would be B12 levels, morphology, and elevated methylmalonic acid levels).

    Source(s): Current Medical Diagnosis & Treatment 2013 by Papadakis and McPhee (ed. by Rabow)
  • tittle
    Lv 4
    4 years ago

    Anemic ability the Hemoglobin, the oxygen wearing part of the crimson blood cellular is under the prevalent on your age. For women persons maximum possibly Iron deficiency, for adult males, maximum possibly blood loss.

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