It depends on many different things. Even though they set up charts to state a
lethal dose, it does not apply to everyone. It depends on the cause, also.
Alcohol can cause liver cell damage in different ways:
1) overconsuming alcohol in a short time period doesn't give the liver cells time
to make the necessary enzymes to convert the alcohol to acetaldehyde, then
to acetate, and then to carbon dioxide and water. If the alcohol is not
converted complete to the last step, it can become toxic to the liver cells.
2)consuming alcohol over long time periods can lead to fat build up inside
the liver (fatty liver disease). The fat causes additional pressure inside
the liver that can also damage the liver cells.
3)some people are more sensitive to alcohol and some are even allergic
to it. Alcohol is a drug and just like any other drug...some people may
have little problem consuming it, while others...it doesn't take much to
4)mixing alcohol with medication can lead to an interaction occuring
between them...or the liver is overwhelmed in handling both at the
same time. That can cause instant cell damage.
So, it really depends on a lot of different things whether a dosage would
be lethal or not.
When the liver cells become damaged, the immune system of the body
responds to this and cause inflammation inside the liver. This causes
the liver to enlarge in size and takes on a spongy texture.
This inflammation, if it continues in the liver and the cause is not
stopped can lead to where the liver cells die off and form scar tissue
inside the liver...this is then Fibrosis. When the scar tissue keeps
forming in the liver, it start to connect together...this is
bridging Fibrosis. The scar tissue starts to reconstruct the
liver on the inside and the blood doesn't flow through properly.
The scar tissue prevents healthy cells and regenerated cells
from receiving blood and therefore they continue to die off.
All blood from the entire abdominal area flows through the
portal vein of the liver, to the hepatic vein and then through
the vena cava vessel to the heart. The scar tissue also
prevents this from taking place...the blood backs up
in the portal vein and other smaller WEAK vessels
under the liver (varies) that can break open and
cause internal bleeding. This is now Cirrhosis of
Being detoxed from alcohol is the very first step in preventing
further damage to the liver cells. As long as there is just
inflammation with enlargement...there is a good chance that
it could be reversed. Once it reaches the stage of scar tissue
forming, it will become Cirrhosis...a progressive irreversible
disease. There is a fine line between the two.
A liver biopsy is the best test known to determine this.
Most all Transplant centers require a patient who is
addicted to alcohol, to be detoxed (under doctors care)
for a period of six month prior to being referred to them
for the evaluation process of being placed on the liver
transplant list. It is sad that many don't live to make
it during that period of time.
Here is a chart you might want to look at:
0.02 Slight mood changes.
0.05-0.06 Impairment starts at .05
Lowered inhibition, impaired judgement, decreased rational decision making ability.
0.08 Legally drunk, deterioration of reaction time & control. Driving is dangerous.
0.10-0.12 Memory and judgment, and motor skills are markedly impaired;
lack of coordination and balance; recognition of impairment is lost;
impotence can occur; increasing belligerence in some. Driving is extremely dangerous.
.15 Impaired balance, movement and coordination. Difficulty standing, walking or talking.
Blackouts (periods of amnesia for all or part of drinking episode) occur for some at
the .14-.17 level.
.20 Decreased pain & sensation. Erratic emotions. Nausea/vomiting may occur.
Risk for asphyxiation on own vomit.
.30 Semi-conscious. Diminished reflexes.
.40 Loss of consciousness (comatose). Very limited reflexes. Anesthetic effects.
Death possible due to respiratory arrest.
.50 Deep coma and death due to anesthesia of nerve centers controlling respiration
>.50 Half the people who reach this level die.
I hope this information has been of some help to you.