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How would the loss of acetylcholinesterase from the neuromuscular junction affect skeletal muscle?

a. it would cause rigid paralysis due to many more action potentials that usual

b. it would cause flaccid paralysis due to lack of muscle action potential

c. it would produce muscle weakness

d. it would have little effect on skeletal msucles

2 Answers

  • 8 years ago
    Favorite Answer

    The answer is a.

    The reason is that acetyl choline (ACh), the transmitter compound, must be degraded by cholinesterase to prevent false signals or double stimulation. Loss of cholinesterase means that the same molecule of acetylcholine can activate the same receptor over and over again. That will cause rapid firing of muscle action potential, and will cause tetany and muscle rigidity.

    Source(s): Medical student
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  • ?
    Lv 4
    4 years ago

    Hi Yes you can have MS and not have lesions visible on MRI. There are lots of reasons why. The one I inderstand best is because they can be deep in the brain and also on the optic nerve. Make sure when you do schedule an mri it is with and without contrast and... make sure the do the spine as well, not just the brain. Many more doctors are now willing to dx based on clinical evedince and evidence of 2 or more recorded exacerbations. Good luck to you, Gina

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