What are excitatory and inhibitory thresholds?
I need some basic definitions and examples of them for my psych test cuz i just want to get the idea.
- 8 years agoFavorite Answer
Postsynaptic conductance changes and the potential changes that accompany them alter the probability that an action potential will be produced in the postsynaptic cell. At the neuromuscular junction, synaptic action increases the probability that an action potential will occur in the postsynaptic muscle cell; indeed, the large amplitude of the EPP ensures that an action potential always is triggered. At many other synapses, PSPs actually decrease the probability that the postsynaptic cell will generate an action potential. PSPs are called excitatory (or EPSPs) if they increase the likelihood of a postsynaptic action potential occurring, and inhibitory (or IPSPs) if they decrease this likelihood. Given that most neurons receive inputs from both excitatory and inhibitory synapses, it is important to understand more precisely the mechanisms that determine whether a particular synapse excites or inhibits its postsynaptic partner.
The principles of excitation just described for the neuromuscular junction are pertinent to all excitatory synapses. The principles of postsynaptic inhibition are much the same as for excitation, and are also general. In both cases, neurotransmitters binding to receptors open or close ion channels in the postsynaptic cell. Whether a postsynaptic response is an EPSP or an IPSP depends on the type of channel that is coupled to the receptor, and on the concentration of permeant ions inside and outside the cell. In fact, the only factor that distinguishes postsynaptic excitation from inhibition is the reversal potential of the PSP in relation to the threshold voltage for generating action potentials in the postsynaptic cell.
Consider, for example, a neuronal synapse that uses glutamate as the transmitter. Many such synapses have receptors that, like the ACh receptors at neuromuscular synapses, open ion channels that are nonselectively permeable to cations. When these glutamate receptors are activated, both Na+ and K+ flow across the postsynaptic membrane. The reversal potential (Erev) for the postsynaptic current is approximately 0 mV, whereas the resting potential of neurons is approximately -60 mV. The resulting EPSP will depolarize the postsynaptic membrane potential, bringing it toward 0 mV. For the particular neuron shown in the action potential threshold voltage is -40 mV. Thus, the EPSP increases the probability that the postsynaptic neuron will produce an action potential, defining this synapse as excitatory. Reversal potentials and threshold potentials determine postsynaptic excitation and inhibition.
However, not all inhibitory synapses produce hyperpolarizing IPSPs. For instance, in the neuron just described, if ECl were -50 mV instead of -70 mV, then the synapse would still be inhibitory because the reversal potential of the IPSP remains more negative than the action potential threshold (-40 mV). Because the electrochemical driving force now causes Cl- to flow out of the cell, however, the IPSP is actually depolarizing. Nonetheless, this depolarizing IPSP inhibits the postsynaptic cell because the cell's membrane potential is kept more negative than the threshold potential for action potential initiation. Another way to think about this peculiarity is that if another depolarizing input were to bring the cell's resting potential to -41 mV, just below threshold for firing an action potential, the opening of these GABA-activated channels would result in a hyperpolarizing current, bringing the membrane potential closer to -50 mV, the reversal potential for these channels. Thus, while EPSPs depolarize the postsynaptic cell, IPSPs can hyperpolarize or depolarize; indeed, an inhibitory conductance change may produce no potential change at all and still exert an inhibitory effect.
Although the particulars of postsynaptic action can be complex, a simple rule distinguishes postsynaptic excitation from inhibition: An EPSP has a reversal potential more positive than the action potential threshold, whereas an IPSP has a reversal potential more negative than threshold. Intuitively, this rule can be understood by realizing that an EPSP will tend to depolarize the membrane potential so that it exceeds threshold, whereas an IPSP will always act to keep the membrane potential more negative than the threshold potential.
- Anonymous4 years ago
I am not 100% on this, however I don't suppose that inhibitory potentials can, due to the fact an inhibitory advantage does no longer try to method the edge, it quite simply keeps the phone at its resting capabilities. Certainly excitatory potentials can, but I don't feel inhibitory potentials summate.
- 8 years ago
different releases of energy for neural impulseSource(s): psych expert