There really isn't anything you can do to make them more effective. Anything you do to enhance them won't make much of a difference at all. There are, however, things you can to do to make them LESS effective. Smoking them will do that, and making a tea out of them will do that as heat destroys the active components in the kava. Snorting them will make it less effective, as all that does is put the stuff in your sinuses. The kava won't absorb into your sinuses, but eventually works its way to the back of your throat where it gets swallowed. You can inject it, but that would probably kill you dead real fast.
Just take them with water. If you want to speed up how fast they hit, take them on an empty stomach (and hope they don't upset your stomach).
And make sure they are good quality pills. The ones you buy at healthfood stores are not always all that great. You will have better results if you by them from a grower. There are several out there, google kava growers. I buy from www.konakavafarms.com, they sell their own produce on their website for reasonable prices.