Animal "helpers" and totems and spirit guides, etc. etc. etc. are all a New Age thing. This is not an indigenous belief or even within the realm of any traditional concept about spirituality.
Then the other issue is what your family "talks about." That is a completely different thing. Your family could just be claiming "Cherokee" blood with no community ties or actual tribal affiliation (meaning, enrolled and from a fullblood community in Eastern Oklahoma or Qualla Boundary) and they just happen to like wolves. Then, you think this has some significance in "Cherokee" culture.
FYI - To claim a fullblood grandparent you should know that there are no fullbloods living now or in the last couple of generations that do not have direct family ties to the few fullblood families and communities in Eastern Oklahoma or in Qualla Boundary rez. A 4/4 Cherokee grandparent would have these ties with absolutely no exception. He should also be enrolled, more than likely (and you should too if you have legit affiliation). These fullblood communities are pretty well known and tight-knit. Fullblood families are known in the community, and they are almost always quite "extended." So, you should be able to ask your heavy blood, tradish relatives.
Cherokees in general do not talk about wolves, or animal helpers or whatever. Now, of course there are always exceptions to the rule and I'm sure there might be some Cherokee folks that dabble in New Age stuff, but it is not "Cherokee," nor is it very common.
Oh, and if you want to get negative reaction (or teased) in Indian Country, all you have to do is talk about your "part-Cherokee" blood (better if you are NOT enrolled), how you dream of wolves and then ask if wolves have spiritual significance. THEN, get indignant at the answers putting your question into proper place. I can tell you, these answers here pretty much sum up the feeling to this question for most Natives. This ain't the first time Natives have heard this same kind of claim/question and it gets the same reaction just about everytime.