It depends on how long you are taking the prednisone really. My mother was on oral prednisone for a week because of a spinal stenosis in her cervical spine, and her side effects included constipation, increase in appetite, nausea, flushing, and fatigue.
Prednisone is a glucocortoid hormone. It resembles a hormone we naturally produce in our adrenal glands called cortisone.
If you are prescribed to be on prednisone for a long time (which I STRONGLY recommend you avoid) you will be overloading your body with these hormones, and in an attempt to rebalance this your body will shut down adrenal production of cortisone. Therefore, if you withdraw from the prednisone, you will have no glucocortoid hormones in your system, and you will face crazy side effects (including possible death).
Long term use of prednisone or other glucocortoids has a devastating impact on your bones. The hormones will cause you to absorb less calcium in your intestines, cause your bones to take in less calcium, cause your bones to rebuild more slowly, and cause them to break apart faster. This can lead to steroid induced osteoporosis, this happened to my grandmother when she took prednisone for years to treat her emphysema. She lost so much bone that she couldn't walk and ended up bound to a wheelchair.
Glucocortoids such as prednisone also slow down the immune system, so you will be more prone to infection and possibly have an increased risk of getting cancer. Your blood sugar will also go up, and you could end up with steroid induced diabetes. Your muscles will also atrophy since these hormones are catabolic, meaning destructive, so you will get weak. Your body will also retain more water and get really puffy, something called "moon face". Your skin will also become more fragile and prone to cutting.
I hope your doctor isn't planning on long term treatment with prednisone, you will be setting your body up for direct destruction. Perhaps you could receive a local prednisone injection in just that area where your nerve is inflamed? Since the injection is local and typically applied at most monthly, you will not suffer from these side effects. The prednisone tablets did not work for my mom so she received an epidural shot of prednisone, worked like a charm, no side effects whatsoever (except some tenderness in the injection area, which is expected). I would never let her take prednisone tablets for an extended period of time.
Hope my words help you out, please talk to your doctor if he is planning long term use, try alternatives. If he is planning short term use, just listen to his instructions and take it in the morning for the amount of time you're supposed to.
Just a kid with knowledge.