Anonymous
Anonymous asked in HealthDiseases & ConditionsOther - Diseases · 9 years ago

what information do we know about parkinson's disease as a result of the Human Genome Project?

in doing a school project on parkinsons and i dont know anything about the human genome project! can someone help?

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    9 years ago
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    Although I am not going to attempt to do your work, you were very wise to ask for direction and clarification.

    The Human Genome Project info can be found at the links below.

    http://www.genome.gov/10001772

    Please see the links within the site as well.

    Project goals were to:

    * Identify all the approximately 20,000-25,000 genes in human DNA,

    * Determine the sequences of the 3 billion chemical base pairs that make up human DNA,

    * Store this information in databases,

    * Improve tools for data analysis,

    * Transfer related technologies to the private sector, and

    * Address the ethical, legal, and social issues (ELSI) that may arise from the project.

    http://www.ornl.gov/sci/techresources/Human_Genome...

    More explanation can be found at Wikipedia:

    https://secure.wikimedia.org/wikipedia/en/wiki/Hum...

    One important piece of information was the genetic similarity between humans and other species such as a fruit-fly which can be used as a Parkinson's disease model when studying aspects of the disease or possible treatments.

    "Researchers have found that two-thirds of human genes known to be involved in cancer have counterparts in the fruit fly. Even more surprisingly, when scientists inserted a human gene associated with early-onset Parkinson's disease into fruit flies, they displayed symptoms similar to those seen in humans with the disorder, raising the possibility the tiny insects could serve as a new model for testing therapies aimed at Parkinson's.

    More recently, a comparative genomic analysis of six species of yeast prompted scientists to significantly revise their initial catalog of yeast genes and to predict a new set of functional elements thought to play a role in regulating genome activity"

    http://www.genome.gov/11509542

    You might also want to read this article specifically about heredity and Parkinson's disease from the Human Genome Institute:

    http://www.genome.gov/10001217

    Research into PD genetics is far from completed. It is interesting to see the change in the origin knowledge base. 10 years ago it was thought that perhaps 3% of all PD cases were genetic in origin. Now it is thought that between 17-20% of patients have a genetic form with an environmental trigger. That number will continue to change it is felt as more is learned. The HGP (Human Genome Project) data will take years to analyze. Gathering the data was just the beginning.

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