Generally, all energy healing practices have similarities. They all work the the healing energies, most involve laying hands on the body. There are variations in practice and variations in what specific energy frequencies the healer is working with. I can not speak for Pranic healing but Reiki does help heal Karmic issues. I believe that most energy modalities can.
If you are trying to choose a modality for yourself, I suggest talking to the different practitioners in your area. Ask them about their training and their healing philosophy. See who seems the most professional and who you feel most comfortable with. If there is more than one practitioner in your area that you feel comfortable with, try a few and see which one you like the best.
Don't worry about the skeptics. Do your own research, there is plenty of scientific research as well as anecdotal evidence about the effectiveness of energy healing, if you care to do your research. Personal experience is better than research, you will see how these things work for you.
Best wishes to you in your search.