Another Anatomy question?

How does the enzyme pepsin get formed? Gastric juice formation in the stomach is regulated by neural and hormonal factors. Please explain what this means.

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  • Anonymous
    10 years ago
    Favorite Answer

    Chief cells secrete the inactive form of the enzyme, referred to as pepsinogen. Pepsin is formed as pepsinogen interacts with the hydrochloric acid secreted from the parietal cells.

    Gastric juice is produced continuously, but its rate of production varies, and is controlled by both neural and hormonal factors. Gastric secretion is inhibited by the hormone somatostatin, which is secreted by specialized cells within the gastric glands. By contrast, the acetylcholine (ACh) released in response to parasympathetic nerve impulses suppresses the release of somatostatin. This stimulates the gastric glands to secrete gastric juice. Parasympathetic impulses also trigger the release of the hormone gastrin, which further stimulates secretion from the gastric glands.

    Source(s): A.S. in Liberal arts and sciences (concentration in science and mathematics)
  • Anonymous
    10 years ago

    The hormone gastrin and stimulation of the vagus nerve cause the stomach lining to secrete Pepsinogen and HCl into the gastric cavity. In the acidic environment created by the HCl, the pepsinogen breaks down into it's active form, called Pepsin. Pepsin aids in the conversion of additional pepsinogen to pepsin, and also breaks down proteins at the N-terminal ends of aromatic amino acids.

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