your question is to vague. the cost of the 2008 budget for nasa was 18 billion dollars,and the cost of the 2010 shuttle program was 3.3 billion dollars. So, we can figure that for the thirty years that the shuttle program went on, the basic facts that make up the shuttle budget are, building 6 orbiters or shuttle ships, building the rockets to launch, building the platforms to launch from, refurbishing the orbiter or to be relaunched, as well as rebuilding the two side rockets, and the salaries and wages that make up the shuttle team needed to monitor the program, and the cost of the cargo the shuttle sent into space, would make up the 3.3 billion dollar budget for 2008. we can guess that the cost for 2011 would not be as high cause there were probably less launches in 2011, the year the program ended.
you could figure that inflation would be about 5% from 2008 to 2011, but the cost for the year would probably be lower than previous years cause the program had less missions due to the end of the program.
my guess is that it would cost about 500 million dollars for an average launch, which includes the cost of employees needed to work between launches.