求英文翻譯 20點

Bone metastases are usually treated by surgical removal,fixation and chemotherapeutic treatment. Bone cement is used to fill the resection voids. The aim of this study was to develp a local drug delivery system using a calcium phosphate cement(CPC磷酸鈣鹽類水泥 ) as carrier for chemotherapeutic agents.CPC consisted of... show more Bone metastases are usually treated by surgical removal,fixation and chemotherapeutic treatment. Bone cement is used to fill the resection voids. The aim of this study was to develp a local drug delivery system using a calcium phosphate cement(CPC磷酸鈣鹽類水泥 ) as carrier for chemotherapeutic agents.CPC consisted of alpha-tricalcium phosphate,calcium phosphate dibasic and precipitated hydroxyapatite powders and a 2% Na2HPO4 hardening solution.Scanning electron microscopy(SEM掃描電子顯微鏡) was used to observe CPCmorphology. X-ray diffraction (XRDX光繞射) was used to follow CPC transformation. The loading/release capacity of the CPC was studied by a bovine serum albumin-loading model. Release/retention was measured by high performance liquid chromatography and X-ray photoelectron spectrometry. For chemotherapeutic loading, paclitaxel(PX紫杉醇) was loaded onto the CPC discs by absortion. Viability of osteosarcoma U2OS and metastatic breast cancer MDA-MB-231 cells was measured by an AlamarBlue assay. Results of SEM and XRD showed changes in CPC due to its transformation. The loading model indicated a high retention behavior by the CPC composition. Cell viability tests indicated a PX minimal lethal dose of 90μg/ml. PX released from CPC remained active to influence cell viability. In conclusion, this study demonstrated that CPC is a feasible delivery vector for chemotherapeutic agents.
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