What would happen to muscles if ACh were to be blocked somehow? Would the muscles weakened? Brief explanation?
if you can.
- 9 years agoFavorite Answer
This is exactly what happens in the muscular disease Myasthenia gravis. The muscles would no longer be able to contact due to blockage of neuromuscular transmission as no ACh can bind the receptors of the motor end plate which means there is no depolarisation of the motor end plate and therefore an action potential can not be initiated to stimulate contraction of the muscle. This eventually does lead to weakening of the muscles due to lack of use.Source(s): I think it would be helpful for you to look up Myasthenia gravis... http://en.wikipedia.org/wiki/Myasthenia_gravis
- Anonymous9 years ago
If Ach is blocked, then the motor end plates (the neurons on the muscles) would not be stimulated, since Ach is needed for muscular movement. If Ach is blocked, the muslces would atrophy and mobility would eventually be deficient/impossible.