what is virus attenuation?
- JayMLv 71 decade agoFavorite Answer
An attenuated virus is one that can still cause infection, but no longer causes disease. The MMR vaccine and the Sabin Oral polio vaccines are examples. In the Sabin vaccine, for example, the viruses used to make the vaccine preparation possess mutations that render them incapable of replicating in the central nervous tissue. CNS infection results in paralysis. Attenuated vaccines produce more robust immune responses because they mimick a natural infection. These attenuated vaccines also induce cell-mediated immunity along with the humoral antibody response which confers more complete immunity.
- 1 decade ago
It is when the virulence of the virus is reduced, frequently done for use in vaccines.