What type of chromosomal alteration must occur for bcr-abl to be made?
As It Relates To Leukemia.
- Anonymous9 years agoFavorite Answer
The BCR-ABL fusion proteins are formed by an unknown mechanism usually by a reciprocal translocation t(9;22)(q34;q11). The resulting protein has components from the breakpoint cluster region protein at the amino terminus giving it serine-threonine kinase activity and tyrosine kinase Abelson murine leukaemia protein (ABL) which has nucleus, DNA and actin binding sites.