How do you differentiate between AML-M4 and AML-M5?

I know that both can contain monoblasts and myeloblasts. Is the difference have to do with the percent of monoblasts? Thanks.

Update:

Thank you for that wikipedia entry...I already know what you told me, but thanks. Anyone else?

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  • fss
    Lv 4
    1 decade ago
    Favorite Answer

    AML-M4

    Acute myelomonocytic leukemia (AMMoL) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.

    It is classified under "M4" in the French-American-British classification.

    AML-M5

    Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia.

    In order to fulfill World Health Organization (WHO) criteria for AML-5, a patient must have greater than 20% blasts in the bone marrow, and of these, greater than 80% must be of the monocytic lineage. A further subclassification (M5a versus M5b) is made depending on whether the monocytic cells are predominantly monoblasts (>80%) (acute monoblastic leukemia) or a mixture of monoblasts and promonocytes (<80% blasts). Monoblasts can be distinguished by having a roughly circular nucleus, delicate lacy chromatin, and abundant, often basophilic cytoplasm. These cells may also have pseudopods. By contrast, promonocytes have a more convoluted nucleus, and their cytoplasm may contain metachromatic granules.

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