Well, it definitely feels strange for the first time you try, but you will get used to it after awhile.
(Actually, since I've used it for a pretty long time I just use the pen like my mouse).
The colors, tone, shading matter now-basically because the tools are easier to use. I suggest you do layers to start with. You may struggle at first, but you might want to check out some tutorials online. Trust me, digital art tutorials will help you a LOT. Check out deviantart.com or search up on youtube.com if you need tutorials.
Wait. If you're going to start digital art, do you have a program for it? If you need one, I would suggest Corel or SAI (SAI is difficult if you're just starting though).
My experience :D