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幫我翻譯這篇醫學英文~儘量不要用線上翻譯軟體~ From June 2004 to June 2008, patients were recruited from 12 Italian ICUs. Review boards approved the protocol and patients or their proxy (the family or the referring physician not involved in the study) provided written consent.17 Patients were enrolled in the study if they... show more 幫我翻譯這篇醫學英文~儘量不要用線上翻譯軟體~

From June 2004 to June 2008, patients were recruited from 12 Italian ICUs.
Review boards approved the protocol and patients or their proxy (the family or
the referring physician not involved in the study) provided written consent.17
Patients were enrolled in the study if they were older than 18 years, had
been mechanically ventilated for acute respiratory failure for 24 hours, had a
Simplified Acute Physiology Score II between 35 and 65,18 had a sequential organ failure assessment (SOFA) score equal to or greater than 5,19 and did not
have a pulmonary infection (estimated by a Clinical Pulmonary Infection
Score [CPIS] of _6).20,21 Patients were excluded from the study if they
had chronic obstructive pulmonary disease; an anatomical deformity of the
neck (including thyromegaly) and cervical
tumors; a history of esophageal, tracheal, or pulmonary cancer; previous
tracheotomy; soft tissue infection of the neck; hematological malignancy;
or were pregnant.

Tracheotomy was not performed if one of the following a priori–defined
conditions occurred: improvement in
oxygenation (identified as a PaO2 _60
mm Hg, a FiO2_50%, and a PEEP_8
cm H2O) and the attending physician
determined that the acute clinical condition
resolved that had required the
mechanical ventilation; moribund state
or death; intracranial pressure greater
than 15 mm Hg and/or cerebral perfusion
pressure less than 60mmHg22; or
platelet count of 50 000 cells/µL or less,
activated partial thromboplastin time or
prothrombin time longer than 1.5 seconds,
or bleeding time greater than
twice normal in the 24 hours prior to
the scheduled tracheotomy. Patients
randomized to the early or late tracheotomy
group who did not receive the
planned procedure were still included
in the final analysis due to the intentionto-
treat design.
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