Acquired Immunity after Blood Transfusion?
If a person suffers massive blood loss from trauma, etc., does he/she lose some memory B cells of a certain antigen thereby eliminating his/her acquired immunity for that antigen? If that person receives a blood transfusion, does he incorporate memory B cells from that blood?
- BloodDocLv 71 decade agoFavorite Answer
White cells are present in all cellular blood components, including leukoreduced RBC's and platelets. If the patient's immune system is competent, transfused wbc's will be targeted and removed by the recipient's reticuloendothelial system. A rare problem, called Transfusion Associated Graft Versus Host Disease (TA-GVHD) may arise if the donor and recipient share white cell HLA haplotypes, but this involves immunocompetent donor T-lymphocytes. The vast majority of B-cells are located in the spleen and lymph nodes. While plasma immunoglobulin levels may be depleted during massive transfusion, the body will replenish these with time as the patient recovers.
Some studies have shown a transient decrease in cell-mediated immunity following the transfusion of cellular blood products, even autologous blood. It has been suggested that any transfusion may increase the risk of post-transfusion infections or recurrence of malignancies following surgery.Source(s): Transfusion Medicine Physician
- The Big KLv 51 decade ago
Most times, during a trauma, the person receives packed red blood cells as the transfusion. There are no white blood cells given, and red cells do not confer immunity.