Of course, "Stand up, Chuck!" has to win for the sheer pie-in-the-face brilliance of it. And the added touch of "up chuck" doesn't hurt, either.
But since others chose that one, I'll choose this, because it's two for the price of one:
"When the stock market crashed, Franklin Roosevelt got on television and didn't just talk about the, uh, you know, "Princes of Greed", he said, "Look, here's what happened." -- Joe Biden