Not at all.
Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI), a class of antidepressants. Zoloft it also an anti-anxiety medication.
Zoloft produces its effect by acting on the serotonin transporter (SERT) in a manner that causes increased concentrations of serotonin in the cellular synapse and the increased receptor binding that would occur.
The Food and Drug Administration (FDA) approved indications for Zoloft: Major Depressive Disorder, Obsessive-Compulsive Disorder (OCD), Posttraumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), and Social Anxiety Disorder ("social phobia").
Health Canada approved indications for Zoloft: Major Depressive Disorder, Obsessive-Compulsive Disorder (OCD), and Panic disorder with or without agoraphobia.
Other legitimate and medically accepted uses of Zoloft include treatment for Seasonal Affective Disorder, dysthymia (less severe but long lasting form of depression) bulimia nervosa, irritable bowel syndrome, premature ejaculation, and treating anxiety and/or depression associated with other mental illness like bipolar.
Adderall is a mix of 75% dextroamphetamine and 25% leveoamphetamine. Almost all effects, especially the beneficial ones, are due to the dextroamphetamine. Adderall is "speed," it is not like speed it is true 100% "speed." Adderall is approved to treat ADHD and narcolepsy, a rare and debilitating sleeping disorder. Other legitimate and medically accepted uses of amphetamines, including Adderall, are for use as an adjunct to opioid analgesics for treatment of severe intractable pain, for use as an adjunct to opioid analgesics to reduce sedating side effects, treatment of drug induced brain dysfunction, treatment of epilepsy, treatment of depression shown to be refractory to other therapeutic modalities, treatment of primary idiopathic hypersomnia and other sleeping disorders causing clinically, significant excessive daytime sleepiness (EDS), as part of a differential diagnostic psychiatric evaluation of depression, during acute, severe situations of depression requiring rapid symptomatic relief, in addition some doctors (myself included) do consider amphetamine use for weight loss to be acceptable in some grave situations, typically when the patient is at risk of or has developed potentially lethal complications from weight loss. However legitimate cases when amphetamines may be considered for weight loss are uncommon. Amphetamines may also be used under specific situations in the military.
Amphetamines, unlike antidepressants like Zoloft, have a large number of actions. in a nut shell amphetamines do cause some of the pharmacologic effects of Zoloft however amphetamines act on serotonin, norepinephrine, and dopamine along with their transporters. Amphetamines have actions like a different class of antidepressants called MAOI's, and most importantly what distinguishes amphetamine from an antidepressants is that amphetamines are releasing agents meaning that amphetamine will pump out vast amounts of neurotransmitters like dopamine.
Also Adderall and other amphetamines have a significant potential for abuse and at doses used by addicts amphetamines are neurotoxic. Zoloft has no recreational value and it is not addictive.
M.D., C.M. psychiatry, internal medicine (Québec)
Hons. BSc in pharmacology