I will offer my take on your question. Forget about the so called self seal tires. Not worth the money. I use standard tubes, no liners, and kevlar belted tires. This along with airing up the tires every day or two helps keep flats to zero to two a year. EVERY bicyclists needs to know how to deal with a flat tire. This is the most common problem a bicyclist faces. I carry tire irons, two spare tubes, patch kit, and frame mounted pump. I carry on my tandem a spare folding bead tire.
One year I rode about 2,200 miles on 700 x 20 Avocet tires without a single flat. Inner tubes were thin for racing. Wore the rear tire down to the cords. I weighed about 180 pounds that summer.