Acetylcholine and GABA question?

When the post synaptic membrane is stimulated by acetylcholine, an action potential is less likey if GABA is released at the same time.Explain Why??

6 Answers

Relevance
  • 10 years ago
    Best Answer

    coz GABA production is inhibitng the formation of acetylcholine

    Source(s): :)
  • 10 years ago

    Acetylcholine is an excitatory neurotransmitter. The channels it activates are mostly permeable to sodium and/or calcium. Both of these ions will enter the cell when the channels open and cause the membrane potential to be less negative (depolarize) and fire an action potential if the threshold is crossed.

    GABA is an inhibitory neurotransmitter. The channels it activates are permeable to chloride only. Chloride enters the cell through these channels and causes the membrane potential to be more negative (hyperpolarization). This puts the membrane potential further away from threshold and so the AP is less likely to result.

    Source(s): many years of studying electrophysiology
  • 10 years ago

    GABA receptors generally exist on post synaptic membranes within the central nervous system, and generally serve to alter the membrane potential and inhibit the postsynaptic neuron. Alcohol, Valium, and other major classes of sedatives act on these GABA receptors, having an overall sedating effect.

  • 10 years ago

    GABA inhibites the production of acetylcholine, which stop the action potential of continuing

  • How do you think about the answers? You can sign in to vote the answer.
  • 10 years ago

    GABA is an inhibitory neurotransmitter. It functions by association with trans-membrane protein receptors. When bound, ion channels open allowing chloride and potassium ions to flow freely, which results in hyper-polarization. Acetylcholine works by using targeted ion flow to excite neurons, but because of the actions of GABA opening the ion channels and allowing the ions to flow freely, acetylcholine is unable to illicit an effect.

  • Dr Owl
    Lv 5
    10 years ago

    When the GABA binds to the GABAa receptor, it causes an influx of negative chloride ions into the cell which hyperpolarises it, thus inhibiting depolarisation by other neurotransmitters.

    Source(s): My head, not cut-and-pasted from another website ;)
Still have questions? Get your answers by asking now.