scott asked in 科學化學 · 1 decade ago

[化學.分析]請幫我翻譯一段文章..有點急

The selectivity of this method was evaluated by analyzing six

lots of pooled human serum in comparison with LLOQ samples.

There were no peaks observed in any of the pooled human serum

samples at the retention time of the azoles respectively the internal

standard. No ion suppression was observed by analyzing six

lots of pooled human serum and simultaneously direct infusion of a

stock solution containing fluconazole or voriconazole or posaconazole

or itraconazole-hydroxyitraconazole and cyanoimipramine by

a syringe pump.

不要翻譯軟體或GOOGLE

拜託了...有點急 >"<

2 Answers

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  • 1 decade ago
    Favorite Answer

    你這篇文章出自於

    Method for therapeutic drug monitoring of azole antifungal drugs in human serum using LC/MS/MS,

    Journal of Chromatography B

    Volume 878, Issue 1, 1 January 2010, Pages 39-44

    原文的章節標題是: Selectivity and interference

    主要在談兩件事: 方法選擇性與干擾

    第一句話: The selectivity of this method was evaluated by analyzing six lots of pooled human serum in comparison with LLOQ samples

    說明如何評估選擇性: 以LC/MS/MS 分析6 批混合的人類血清並且與濃度在可定量下限的標準品溶液比較,

    There were no peaks observed in any of the pooled human serum

    samples at the retention time of the azoles respectively the internal standard.

    在 azoles 與內標物的滯留時間都未發現訊號(表示其他物質不會干擾, 選擇性很好)

    No ion suppression was observed by analyzing six

    lots of pooled human serum and simultaneously direct infusion of a

    stock solution containing fluconazole or voriconazole or posaconazole or itraconazole-hydroxyitraconazole and cyanoimipramine by a syringe pump.

    這段是在說這個方法(只將蛋白質沉澱即上機) 不會有離子抑制的現象(也就是說MS 的訊號強度不受影響)

    評估的方式是將含有標準品(fluconazole or voriconazole or posaconazole or itraconazole-hydroxyitraconazole and cyanoimipramine) 溶液利用針筒式幫浦與上述混合後的血清直接混合後以 LC/MS/MS 分析, 觀察訊號是否變弱

  • ‵★
    Lv 6
    1 decade ago

    許多和 LLOQ 樣本比較起來告發人類的血清。

    沒有在任何被觀察的峰巔那告發人類的血清

    樣本分別地在 azoles 的維持時間那內在的

    標準。 沒有離子抑壓藉由分析被觀察六

    許多告發人類的血清而且同時地指示注入一

    進貨包含 fluconazole 的解決方案或 voriconazole 或 posaconazole

    或 itraconazole-hydroxyitraconazole 和 cya

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