strong deactivator with a weak activator groups on a benzene ring?

plz... if we have a strong deactivator (like NO2) and a weak activator like (CH3) on the same benzene ring... then if we wanna add another group... who will control the reaction? the weak activator (para-ortho director) or the strong deactivator (meta director)?

thank you very much

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  • 10 years ago
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    I assume you are talking about Electrophilic Aromatic Substitution. It depends on where they are located. If the para-ortho of the weak activator is also the meta of the strong deactivator, then it goes there.

    But if not, the strong deactivator will control the reaction since it will cause a greater decrease in stability if not.

    Source(s): 3rd year Chemical Engineering student
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