1. January 5 – Typhoid fever breaks out in a Seattle jail, the first of 2 typhoid outbreaks in the USA during the year.
2. January 1 - The birth of Pentecostalism at a prayer meeting at Bethel Bible College in Topeka, Kansas.
3. January 7 – Alferd Packer is released from prison after serving 18 years for cannibalism.
4. January 10 – In the first great Texas gusher, oil is discovered at Spindletop in Beaumont, Texas.
5. January 28 – Baseball's American League declares itself a Major League.
6. March 2 – The U.S. Congress passes the Platt Amendment, limiting the autonomy of Cuba as a condition for the withdrawal of American troops.
7. March 4 – United States President William McKinley begins his 2nd term. Theodore Roosevelt is sworn in as Vice President of the United States.
8. April 25 – New York State becomes the first to require automobile license plates.
9. May 3 – The Great Fire of 1901 begins in Jacksonville, FL.
10. May 17 – The U.S. stock market crashes.
11. May 27 – In New Jersey, the Edison Storage Battery Company is founded.
12. June 12 – Cuba becomes a U.S. protectorate.
13. July 24 – O. Henry is released from prison in Columbus, Ohio after serving 3 years for embezzlement from the First National Bank in Austin, Texas.
14. August 28 – Silliman University is founded in the Philippines. The first American private school in the country.
15. September 2 – U.S. Vice President Theodore Roosevelt utters the famous phrase, "Speak softly and carry a big stick" at the Minnesota State Fair.
16. September 5 – The National Association of Professional Baseball Leagues (later renamed Minor League Baseball), is formed in Chicago.
17. September 6 – American anarchist Leon Czolgosz shoots U.S. President William McKinley at the Pan-American Exposition in Buffalo, New York. McKinley dies 8 days later.
18. September 14 – Theodore Roosevelt succeeds William McKinley as President of the United States.
19. September 26 – The body of U.S. President Abraham Lincoln is exhumed and reinterred in concrete several feet thick.
20. October 16 – U.S. President Theodore Roosevelt invites African American leader Booker T. Washington to the White House. The American South reacts angrily to the visit, and racial violence increases in the region.
21. October 23 – Yale University celebrates its bicentennial.
22. October 24 – Michigan schoolteacher Annie Taylor goes down Niagara Falls in a barrel and survives.
23. November 1 – Sigma Phi Epsilon is founded in Richmond, VA.
24. November 28 – The new state constitution of Alabama requires voters to have passed literacy tests.
25. December 3 – U.S. President Theodore Roosevelt delivers a 20,000-word speech to the House of Representatives asking Congress to curb the power of trusts "within reasonable limits."
26. William S. Harley draws up plans for his first prototype motorcycle.
27. The Intercollegiate Prohibition Association is established in Chicago.
That's all I could gather for you in 15 minutes without spending the entire day obsessively looking into history books and websites.