I also have Bipolar Disorder, and I understand how hard it is to make and keep friends. There's really not much you can do about the emotional detachment, but the symptoms of personality disorders are lessened with therapy. I go to weekly therapy visits, and take a mood stabilizer, and I've found that I personally need both to be at my highest functioning.
On the medication issue, most people don't like it. I HATE medication, but it makes life so much more bearable. It depends on the person and how severe the disorder is. It usually does take some experimenting to get the right medication, especially if you've never known what it's like to feel "normal". The road to the right meds is rough...having your brain chemicals adjusted sucks but for me it was worth it.
I have a boyfriend who has been there for me since before I was even diagnosed. I'd say the biggest factor in my "recovery" is the stability of having someone there. He reassures me, helps me out with the apartment if I get stuck in a rut, talked me into going back to counseling, and stuff like that. The biggest thing is to have somebody to talk to and to keep you stable. I worry that it's taxing on him, though. I still have episodes, and it gets really hard for both of us sometimes. It's a challenge, but if you're patient and committed and your wife is committed to working towards her own wellness then it's do-able.
I strongly recomend at least counseling to help your wife understand what she's going through, or at least to try it. It can be expensive, but there are alternatives. I get it from my college for free, and some communies have free support groups.