Anonymous
Anonymous asked in 健康疾病與處置其他:疾病 · 1 decade ago

急 HYPERINSULINEMIA能說明一下大意或翻譯嗎?

Individuals who have selective impairment of insulinstimulated

glucose disposal at the level of skeletal muscle

develop compensatory hyperinsulinemia following

CHO-containing meals. Several lines of evidence suggest

that other insulin-stimulated pathways are, however,

normally responsive to the hormone, becoming therefore

overstimulated following carbohydrate intake. Such conditions

occur, for example at renal tubular level, where

day-long insulin-mediated sodium retention was enhanced

in insulin-resistant, hyperinsulinemic humans,

despite identical dietary intake of both sodium and carbohydrate

[75]. In addition, greater insulin-mediated inhibition

of protein catabolism was also demonstrated in

insulin-resistant as compared to control subjects [42].

We suggest that this overall increase of other insulin

signalling pathways is a pro-aging factor, probably of

greater relevance than hyperglycemia. The degree of

hyperglycemia, seen in glucose-tolerant individuals with

selective muscle resistance to insulin-stimulated glucose

1304 F. C. FACCHINI et al.

metabolism, is, in fact, only of mild (;20–50%) entity

until diabetes ensues.

This hypothesis, although speculative, is supported by

studies in invertebrate and mammalian models where it

was determined that whether overall insulin signalling is

reduced by mutations, like in C. elegans, or by lowered

plasma glucose and insulin levels, as it occurs in the

calorie-restricted rodent, a similar outcome becomes apparent:

extension of lifespan and, at any given age after

maturity, decreased prevalence of ARD.

1 Answer

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  • 提姆
    Lv 7
    1 decade ago
    Favorite Answer

    骨骼肌對於胰島素刺激而代謝葡萄糖有障礙者,在進食含碳水化合物後會產生代償性的高胰島素症。不過有些證據顯示其他胰島素刺激的路徑是對胰島素的反應正常,才造成過度分泌的。這樣的情況,以腎小管為例,雖然吃下等量鈉及碳水化合物,會加強胰島素耐性、高胰島素者胰島素媒介的鈉滯留。另外,胰島素耐性者相對於對照組,有更多胰島素媒介的抑制蛋白質分解。

    我們認為增加整體其他的胰島素傳訊路徑是一個造成衰老的因子,也許比高血糖的相關性更高。在葡萄糖耐性且有骨骼肌胰島素耐性的人,在糖尿病發生前只有部份(約20-50%)有高血糖。這個假說,雖然是假設性的,在胰島素傳訊突變而減少或降低血中葡萄糖及胰島素的非脊椎及哺乳類動物實驗得到支持:結果正如限制熱量的齧齒動物一樣,延長生命並減少成年後老化的相關疾病。

    本文是假設胰島素耐性導致的高胰島素症,才是造成老化的重要因子。

    Source(s): HYPERINSULINEMIA: THE MISSING LINK AMONG OXIDATIVE STRESS AND AGE-RELATED DISEASES?
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