bbkg asked in 科學生物學 · 1 decade ago

問一個Blood coagulation 過程中的小疑問

Blood coagulation的過程裡 凝血因子X 的活化有 intrinsic pathway 和 extrinsic-

pathway 兩種途徑

這兩種途徑的發生 有可能是單一?還是必需兩者都在進行?

因為 intrinsic pathway 中 凝血因子VIII的活化是由IIa完成的

可是IIa需由Prothrombin activator(來自extrinsic pathway)活化凝血因子II而產生

這樣我就不懂了

這意味著這兩種途徑都在進行嗎?

Update:

專家謝謝你^^

很高興有您的回答^^

1 Answer

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  • 1 decade ago
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    Factor VIII 嚴格一點說不完全是局限於 intrinsic pathway。大部分的 coagulation factors 都不是只在單一的 intrinsic/extrinsic pathway 中活化,它們也是會相互影響到另一個pathway 的.

    Although the concept of "intrinsic" and "extrinsic" pathways served for many years as a useful model for coagulation, more recent evidence has shown that the pathways are not, in fact, redundant but are highly interconnected.

    For example, the tissue factor/VIIa complex activates not only factor X but also factor IX of the intrinsic pathway.

    Furthermore, patients with severe factor VII deficiency may bleed even though the intrinsic pathway is intact.

    Likewise, the severe bleeding associated with deficiencies of factors VIII or IX would not be expected if the extrinsic pathway alone were sufficient to achieve normal hemostasis.

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