如何分辨IN FACT和HOWEVER?

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In fact 就是事實上，其實呢

However 是總之，不管怎樣

Ex.

A: Don't you think John has been really nice to you?

B: I don't feel that way, in fact I think he is on to something evil..

(我不這麼覺得，事實上我倒覺得他在計畫什麼壞事)

A: It's really sad that you two broke up..

B: Well, we had some unsolveable issues, however, it's already in the past.

(我們有些沒辦法解決的問題，不管了，都過去了)